| FMR LLC | $2.3B | 0.12% |
| BlackRock, Inc. | $1.5B | 0.03% |
| VANGUARD CAPITAL MANAGEMENT LLC | $1.2B | 0.03% |
| BAILLIE GIFFORD & CO | $1.0B | 1.04% |
| Capital World Investors | $949.8M | 0.13% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $793.3M | 0.04% |
| STATE STREET CORP | $755.0M | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $638.8M | 0.07% |
| GEODE CAPITAL MANAGEMENT, LLC | $478.5M | 0.03% |
| TWO SIGMA INVESTMENTS, LP | $467.7M | 0.38% |
| MORGAN STANLEY | $430.3M | 0.03% |
| UBS Group AG | $423.5M | 0.06% |
| Theleme Partners LLP | $408.9M | 27.24% |
| JANE STREET GROUP, LLC | $373.6M | 0.05% |
| CITADEL ADVISORS LLC | $358.9M | 0.06% |
| GOLDMAN SACHS GROUP INC | $344.0M | 0.04% |
| CITIGROUP INC | $320.0M | 0.14% |
| D. E. Shaw & Co., Inc. | $271.8M | 0.16% |
| Tidal Investments LLC | $257.8M | 0.54% |
| IMC-Chicago, LLC | $255.4M | 0.05% |
| Invesco Ltd. | $243.1M | 0.04% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $240.5M | 0.04% |
| Flagship Pioneering, LLC | $235.3M | 20.26% |
| Alyeska Investment Group, L.P. | $205.8M | 0.58% |
| NATIONAL BANK OF CANADA /FI/ | $166.2M | 0.09% |
| NORTHERN TRUST CORP | $150.0M | 0.02% |
| BANQUE PICTET & CIE SA | $139.6M | 0.98% |
| FIRST TRUST ADVISORS LP | $121.5M | 0.09% |
| WELLINGTON MANAGEMENT GROUP LLP | $119.8M | 0.02% |
| Merck & Co., Inc. | $117.3M | 33.56% |
| JPMORGAN CHASE & CO | $111.7M | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $108.2M | 0.02% |
| Qube Research & Technologies Ltd | $107.0M | 0.12% |
| FEDERATED HERMES, INC. | $100.4M | 0.16% |
| VANGUARD FIDUCIARY TRUST CO | $99.9M | 0.03% |
| Caption Management, LLC | $98.7M | 0.58% |
| Squarepoint Ops LLC | $96.1M | 0.11% |
| SIMPLEX TRADING, LLC | $95.4M | 0.03% |
| Bank of New York Mellon Corp | $85.9M | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $82.3M | 0.02% |
| Douglas Lane & Associates, LLC | $66.6M | 0.96% |
| GROUP ONE TRADING LLC | $64.9M | 0.08% |
| MILLENNIUM MANAGEMENT LLC | $62.1M | 0.03% |
| Walleye Trading LLC | $58.5M | 0.10% |
| LMR Partners LLP | $57.6M | 0.13% |
| Two Seas Capital LP | $55.9M | 0.78% |
| Nuveen, LLC | $54.8M | 0.01% |
| BARCLAYS PLC | $54.4M | 0.01% |
| ROYAL BANK OF CANADA | $52.7M | 0.01% |
| PERCEPTIVE ADVISORS LLC | $50.8M | 0.99% |
| Allianz Asset Management GmbH | $50.2M | 0.05% |
| BANK OF AMERICA CORP /DE/ | $50.1M | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | $49.3M | 0.22% |
| Amundi | $46.0M | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | $44.8M | 0.07% |
| Alphadyne Asset Management LP | $44.2M | 0.77% |
| DEUTSCHE BANK AG\ | $41.2M | 0.01% |
| Affinity Asset Advisors, LLC | $40.6M | 2.10% |
| Lingotto Investment Management LLP | $38.8M | 0.77% |
| Legal & General Group Plc | $38.1M | 0.01% |
| LETKO, BROSSEAU & ASSOCIATES INC | $38.0M | 0.61% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $37.5M | 0.00% |
| Vanguard Global Advisers, LLC | $37.4M | 0.02% |
| Point72 Asset Management, L.P. | $36.3M | 0.05% |
| Russell Investments Group, Ltd. | $36.1M | 0.04% |
| Swiss National Bank | $35.4M | 0.02% |
| Pictet Asset Management Holding SA | $32.8M | 0.03% |
| Step Capital Management Pte. Ltd. | $32.8M | 13.15% |
| California Public Employees Retirement System | $31.9M | 0.02% |
| HSBC HOLDINGS PLC | $28.5M | 0.01% |
| RHUMBLINE ADVISERS | $28.5M | 0.02% |
| CAPSTONE INVESTMENT ADVISORS, LLC | $26.6M | 0.05% |
| PEAK6 LLC | $26.4M | 0.06% |
| Telemark Asset Management, LLC | $25.4M | 2.35% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $24.7M | 0.10% |
| Trexquant Investment LP | $24.6M | 0.18% |
| OFI INVEST ASSET MANAGEMENT | $24.2M | 0.32% |
| Susquehanna Portfolio Strategies, LLC | $23.9M | 0.36% |
| Walleye Capital LLC | $23.7M | 0.10% |
| VOYA INVESTMENT MANAGEMENT LLC | $22.3M | 0.02% |
| Mitsubishi UFJ Asset Management Co., Ltd. | $21.6M | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $20.7M | 0.02% |
| Mount Capital Ltd | $20.1M | 8.09% |
| HRT FINANCIAL LP | $19.7M | 0.05% |
| PRINCIPAL FINANCIAL GROUP INC | $19.7M | 0.01% |
| CWM, LLC | $19.7M | 0.05% |
| TUDOR INVESTMENT CORP ET AL | $19.0M | 0.04% |
| Mitsubishi UFJ Trust & Banking Corp | $17.3M | 0.04% |
| BANK OF MONTREAL /CAN/ | $17.2M | 0.01% |
| Leonteq Securities AG | $16.2M | 0.60% |
| VANGUARD ASSET MANAGEMENT, Ltd | $16.2M | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $16.0M | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $15.3M | 0.03% |
| SG Americas Securities, LLC | $14.4M | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | $14.0M | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $13.5M | 0.03% |
| MARSHALL WACE, LLP | $12.7M | 0.01% |
| VAN ECK ASSOCIATES CORP | $12.5M | 0.01% |
| ALGERT GLOBAL LLC | $12.1M | 0.18% |
| Candriam S.C.A. | $11.7M | 0.06% |
| ALLIANCEBERNSTEIN L.P. | $11.6M | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $11.5M | 0.03% |
| PLUSTICK MANAGEMENT LLC | $11.2M | 5.40% |
| DekaBank Deutsche Girozentrale | $10.8M | 0.02% |
| Woodline Partners LP | $10.7M | 0.04% |
| CREDIT AGRICOLE S A | $10.2M | 0.03% |
| SHANDA ASSET MANAGEMENT HOLDINGS Ltd | $10.2M | 0.55% |
| Artia Global Partners LP | $10.2M | 2.03% |
| RAYMOND JAMES FINANCIAL INC | $10.0M | 0.00% |
| WELLS FARGO & COMPANY/MN | $9.8M | 0.00% |
| TWIN FOCUS CAPITAL PARTNERS, LLC | $9.4M | 1.08% |
| TD Asset Management Inc | $9.1M | 0.01% |
| LPL Financial LLC | $9.0M | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $9.0M | 0.01% |
| Chevy Chase Trust Holdings, LLC | $8.7M | 0.03% |
| PRUDENTIAL FINANCIAL INC | $8.7M | 0.01% |
| Bank Pictet & Cie (Europe) AG | $8.6M | 0.18% |
| Quantinno Capital Management LP | $8.5M | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $8.5M | 0.07% |
| Vontobel Holding Ltd. | $8.3M | 0.03% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $8.1M | 0.02% |
| Eversept Partners, LP | $8.1M | 0.43% |
| DIADEMA PARTNERS LP | $8.1M | 1.38% |
| JANUS HENDERSON GROUP PLC | $8.1M | 0.00% |
| Crawford Fund Management, LLC | $8.0M | 1.55% |
| 683 Capital Management, LLC | $7.9M | 0.41% |
| Treasurer of the State of North Carolina | $7.8M | 0.02% |
| CANADA LIFE ASSURANCE Co | $7.5M | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $7.5M | 0.01% |
| GATEWAY INVESTMENT ADVISERS LLC | $7.4M | 0.08% |
| AMERIPRISE FINANCIAL INC | $7.3M | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7.0M | 0.01% |
| Centiva Capital, LP | $7.0M | 0.05% |
| Banco Santander, S.A. | $6.8M | 0.05% |
| SEI INVESTMENTS CO | $6.6M | 0.01% |
| Compagnie Lombard Odier SCmA | $6.4M | 0.08% |
| CHAPIN DAVIS, INC. | $6.4M | 1.42% |
| Twin Tree Management, LP | $6.4M | 0.13% |
| State of New Jersey Common Pension Fund D | $6.1M | 0.02% |
| Rafferty Asset Management, LLC | $5.8M | 0.02% |
| Handelsbanken Fonder AB | $5.7M | 0.02% |
| CREDIT INDUSTRIEL ET COMMERCIAL | $5.5M | 0.43% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $5.3M | 0.02% |
| Parkman Healthcare Partners LLC | $5.1M | 0.52% |
| TANG CAPITAL MANAGEMENT LLC | $5.1M | 0.26% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $5.1M | 0.02% |
| South Dakota Investment Council | $5.1M | 0.10% |
| NEUBERGER BERMAN GROUP LLC | $5.1M | 0.00% |
| Public Sector Pension Investment Board | $5.0M | 0.02% |
| CIBC Bancorp USA Inc. | $5.0M | 0.01% |