| Lynx1 Capital Management LP | $151.3M | 23.92% |
| BVF INC/IL | $121.6M | 3.87% |
| RA CAPITAL MANAGEMENT, L.P. | $107.9M | 1.14% |
| RTW INVESTMENTS, LP | $83.4M | 0.83% |
| FMR LLC | $72.2M | 0.00% |
| Avoro Capital Advisors LLC | $25.3M | 0.25% |
| TORONTO DOMINION BANK | $19.7M | 0.03% |
| Troluce Capital Advisors LLC | $13.9M | 0.85% |
| MILLENNIUM MANAGEMENT LLC | $13.2M | 0.01% |
| Jefferies Financial Group Inc. | $10.0M | 0.07% |
| 5AM Venture Management, LLC | $8.1M | 2.24% |
| BlackRock, Inc. | $6.4M | 0.00% |
| UBS Group AG | $5.8M | 0.00% |
| Squadron Capital Management LLC | $4.6M | 1.67% |
| Foresite Capital Management VI LLC | $4.4M | 0.96% |
| BOOTHBAY FUND MANAGEMENT, LLC | $4.0M | 0.05% |
| CenterBook Partners LP | $3.0M | 0.16% |
| HighVista Strategies LLC | $3.0M | 0.83% |
| MARSHALL WACE, LLP | $1.3M | 0.00% |
| Occam Crest Management LP | $1.1M | 0.68% |
| Trexquant Investment LP | $981.5K | 0.01% |
| AdvisorShares Investments LLC | $942.5K | 0.17% |
| CITADEL ADVISORS LLC | $920.4K | 0.00% |
| XTX Topco Ltd | $732.4K | 0.01% |
| GOLDMAN SACHS GROUP INC | $629.8K | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $569.2K | 0.00% |
| NORTHERN TRUST CORP | $459.6K | 0.00% |
| DIADEMA PARTNERS LP | $377.3K | 0.06% |
| MORGAN STANLEY | $363.2K | 0.00% |
| Virtus Investment Advisers, LLC | $294.1K | 0.08% |
| RENAISSANCE TECHNOLOGIES LLC | $289.8K | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $261.0K | 0.00% |
| JPMORGAN CHASE & CO | $245.7K | 0.00% |
| HighTower Advisors, LLC | $219.3K | 0.00% |
| China Universal Asset Management Co., Ltd. | $189.9K | 0.01% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $157.5K | 0.00% |
| STATE STREET CORP | $155.3K | 0.00% |
| Lion Point Capital, LP | $143.4K | 0.86% |
| Persistent Asset Partners Ltd | $95.5K | 0.04% |
| OSAIC HOLDINGS, INC. | $83.3K | 0.00% |
| BARCLAYS PLC | $61.8K | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $45.5K | 0.00% |
| ROYAL BANK OF CANADA | $36.0K | 0.00% |
| North Star Investment Management Corp. | $30.9K | 0.00% |
| CITIGROUP INC | $24.4K | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | $19.5K | 0.00% |
| WELLS FARGO & COMPANY/MN | $17.6K | 0.00% |
| Arkos Global Advisors | $17.0K | 0.00% |
| Tower Research Capital LLC (TRC) | $9.4K | 0.00% |
| Farther Finance Advisors, LLC | $1.5K | 0.00% |
| SIMPLEX TRADING, LLC | $1.2K | 0.00% |
| Cornerstone Financial Management LLC | $450.0 | 0.00% |
| SBI Securities Co., Ltd. | $281.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $184.2 | 0.00% |