| FMR LLC | $651.9M | 0.03% |
| BlackRock, Inc. | $266.5M | 0.00% |
| RA CAPITAL MANAGEMENT, L.P. | $219.2M | 2.32% |
| WELLINGTON MANAGEMENT GROUP LLP | $217.8M | 0.04% |
| Fairmount Funds Management LLC | $212.9M | 15.38% |
| Avidity Partners Management LP | $176.6M | 35.76% |
| VANGUARD CAPITAL MANAGEMENT LLC | $170.5M | 0.00% |
| Octagon Capital Advisors LP | $163.4M | 18.08% |
| TCG Crossover Management, LLC | $140.7M | 4.03% |
| CITADEL ADVISORS LLC | $138.4M | 0.02% |
| STATE STREET CORP | $117.4M | 0.00% |
| T. Rowe Price Investment Management, Inc. | $108.4M | 0.07% |
| Venrock Adviser, LLC | $99.0M | 3.70% |
| FRED ALGER MANAGEMENT, LLC | $97.5M | 0.43% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $96.3M | 0.01% |
| Polar Capital Holdings Plc | $90.3M | 0.32% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $85.6M | 1.01% |
| FRANKLIN RESOURCES INC | $81.2M | 0.02% |
| Cormorant Asset Management, LP | $79.7M | 4.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $76.9M | 0.00% |
| BRAIDWELL LP | $75.5M | 2.52% |
| BAKER BROS. ADVISORS LP | $71.5M | 0.41% |
| FARALLON CAPITAL MANAGEMENT LLC | $70.2M | 0.40% |
| UBS Group AG | $65.6M | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $54.9M | 5.61% |
| Point72 Asset Management, L.P. | $54.0M | 0.07% |
| Catalio Capital Management, LP | $47.0M | 9.82% |
| GOLDMAN SACHS GROUP INC | $46.0M | 0.01% |
| JENNISON ASSOCIATES LLC | $40.7M | 0.03% |
| Balyasny Asset Management L.P. | $39.8M | 0.05% |
| ALLIANCEBERNSTEIN L.P. | $38.2M | 0.01% |
| Woodline Partners LP | $36.4M | 0.14% |
| SAMLYN CAPITAL, LLC | $36.2M | 0.62% |
| MPM BIOIMPACT LLC | $35.6M | 2.75% |
| Logos Global Management LP | $33.6M | 1.68% |
| Affinity Asset Advisors, LLC | $33.6M | 1.73% |
| Artisan Partners Limited Partnership | $32.1M | 0.05% |
| BARCLAYS PLC | $31.9M | 0.01% |
| Spruce Street Capital LP | $31.3M | 7.53% |
| Sio Capital Management, LLC | $31.1M | 4.45% |
| Bain Capital Life Sciences Investors, LLC | $30.4M | 2.74% |
| AMERIPRISE FINANCIAL INC | $30.1M | 0.01% |
| Vivo Capital, LLC | $29.7M | 2.47% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $29.3M | 0.00% |
| MARSHALL WACE, LLP | $28.7M | 0.03% |
| DIMENSIONAL FUND ADVISORS LP | $27.3M | 0.01% |
| Driehaus Capital Management LLC | $26.6M | 0.20% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $25.6M | 0.00% |
| NORTHERN TRUST CORP | $25.5M | 0.00% |
| LORD, ABBETT & CO. LLC | $25.1M | 0.08% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $24.1M | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | $22.2M | 1.13% |
| MILLENNIUM MANAGEMENT LLC | $22.0M | 0.01% |
| VANGUARD FIDUCIARY TRUST CO | $21.0M | 0.01% |
| RTW INVESTMENTS, LP | $20.8M | 0.21% |
| Freestone Grove Partners LP | $20.1M | 0.14% |
| EVENTIDE ASSET MANAGEMENT, LLC | $18.9M | 0.31% |
| First Turn Management, LLC | $18.5M | 2.07% |
| Nuveen, LLC | $18.3M | 0.00% |
| Candriam S.C.A. | $17.9M | 0.09% |
| Ensign Peak Advisors, Inc | $17.1M | 0.03% |
| Jefferies Financial Group Inc. | $17.0M | 0.12% |
| BANK OF AMERICA CORP /DE/ | $15.8M | 0.00% |
| Bank of New York Mellon Corp | $15.8M | 0.00% |
| PFM Health Sciences, LP | $14.4M | 1.32% |
| Artia Global Partners LP | $13.7M | 2.74% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $13.4M | 0.02% |
| Caption Management, LLC | $12.9M | 0.08% |
| Walleye Capital LLC | $12.9M | 0.05% |
| Integral Health Asset Management, LLC | $12.6M | 0.60% |
| D. E. Shaw & Co., Inc. | $12.6M | 0.01% |
| Tri Locum Partners LP | $12.2M | 1.71% |
| Invesco Ltd. | $11.0M | 0.00% |
| Russell Investments Group, Ltd. | $10.8M | 0.01% |
| Atika Capital Management LLC | $10.8M | 1.70% |
| TD Asset Management Inc | $9.8M | 0.01% |
| LMR Partners LLP | $9.8M | 0.02% |
| Hudson Bay Capital Management LP | $9.2M | 0.03% |
| Atom Investors LP | $9.0M | 0.65% |
| SummitTX Capital, L.P. | $8.4M | 0.26% |
| SEVEN GRAND MANAGERS, LLC | $8.4M | 0.56% |
| MORGAN STANLEY | $8.2M | 0.00% |
| Cinctive Capital Management LP | $7.9M | 0.52% |
| Patient Square Capital LP | $7.9M | 1.40% |
| SEI INVESTMENTS CO | $7.7M | 0.01% |
| ExodusPoint Capital Management, LP | $7.2M | 0.06% |
| STEMPOINT CAPITAL LP | $7.2M | 1.37% |
| Moody Aldrich Partners LLC | $6.9M | 1.24% |
| Rhenman & Partners Asset Management AB | $6.9M | 0.85% |
| AMERICAN CENTURY COMPANIES INC | $6.6M | 0.00% |
| Informed Momentum Co LLC | $6.4M | 0.74% |
| Schonfeld Strategic Advisors LLC | $6.2M | 0.04% |
| Swiss National Bank | $5.8M | 0.00% |
| Nantahala Capital Management, LLC | $5.6M | 0.21% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $5.5M | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $5.1M | 0.00% |
| Trexquant Investment LP | $5.0M | 0.04% |
| NEUBERGER BERMAN GROUP LLC | $5.0M | 0.00% |
| ADAR1 Capital Management, LLC | $4.6M | 0.27% |
| Seven Fleet Capital Management LP | $4.6M | 1.45% |
| Alyeska Investment Group, L.P. | $4.4M | 0.01% |
| Nicholas Investment Partners, LP | $4.3M | 0.31% |
| Burkehill Global Management, LP | $4.2M | 0.21% |
| Evergreen Quality Fund GP, Ltd. | $4.2M | 0.10% |
| NEW YORK STATE COMMON RETIREMENT FUND | $4.0M | 0.01% |
| RHUMBLINE ADVISERS | $3.8M | 0.00% |
| ALGERT GLOBAL LLC | $3.7M | 0.06% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $3.4M | 0.01% |
| LPL Financial LLC | $3.4M | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.4M | 0.00% |
| Squarepoint Ops LLC | $3.3M | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $3.1M | 0.00% |
| ALPS ADVISORS INC | $3.0M | 0.01% |
| HighVista Strategies LLC | $3.0M | 0.82% |
| Blackstone Inc. | $2.9M | 0.01% |
| DEUTSCHE BANK AG\ | $2.6M | 0.00% |
| Rafferty Asset Management, LLC | $2.6M | 0.01% |
| ENVESTNET ASSET MANAGEMENT INC | $2.6M | 0.00% |
| Qube Research & Technologies Ltd | $2.5M | 0.00% |
| JPMORGAN CHASE & CO | $2.5M | 0.00% |
| Rock Springs Capital Management LP | $2.2M | 0.13% |
| DV Trading LLC | $2.2M | 0.05% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $2.2M | 0.02% |
| JANE STREET GROUP, LLC | $2.0M | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $1.9M | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.9M | 0.00% |
| Engineers Gate Manager LP | $1.8M | 0.02% |
| Legal & General Group Plc | $1.8M | 0.00% |
| ArrowMark Colorado Holdings LLC | $1.7M | 0.05% |
| SIG BROKERAGE, LP | $1.7M | 0.04% |
| MetLife Investment Management, LLC | $1.6M | 0.01% |
| Brevan Howard Capital Management LP | $1.6M | 0.01% |
| ROYAL BANK OF CANADA | $1.6M | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1.6M | 0.00% |
| BLAIR WILLIAM & CO/IL | $1.5M | 0.00% |
| PRUDENTIAL FINANCIAL INC | $1.5M | 0.00% |
| PEAK6 LLC | $1.5M | 0.00% |
| Vanguard Global Advisers, LLC | $1.5M | 0.00% |
| Darwin Global Management, Ltd. | $1.5M | 0.04% |
| JANUS HENDERSON GROUP PLC | $1.4M | 0.00% |
| BESSEMER GROUP INC | $1.4M | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $1.3M | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $1.3M | 0.00% |
| PROFUND ADVISORS LLC | $1.2M | 0.04% |
| WELLS FARGO & COMPANY/MN | $1.2M | 0.00% |
| XTX Topco Ltd | $1.1M | 0.02% |
| Fisher Asset Management, LLC | $1.1M | 0.00% |
| Legato Capital Management LLC | $1.1M | 0.10% |
| GLENMEDE TRUST CO NA | $1.0M | 0.01% |
| Lisanti Capital Growth, LLC | $1.0M | 0.26% |