CIK: 0001224962
Total reported value
$5.1B
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | AM6 | Amicus Therapeutics INC | Stock-Other | 12.47% | -1.62% | EXIT | |
| 2 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 9.58% | -0.67% | -12.21% | |
| 3 | SRPT | Sarepta Therapeutics INC | Stock-Healthcare | 6.15% | — | +12.01% | |
| 4 | RTRXEUR | Retrophin INC | Stock-Other | 5.80% | — | +4.88% | |
| 5 | T8S | Tesaro INC | Stock-Other | 3.00% | — | -14.62% | |
| 6 | ✓ | Dyax CORP | Stock-Other | 2.89% | — | -17.95% | |
| 7 | NVROEUR | Nevro CORP | Stock-Other | 2.62% | — | +43.43% | |
| 8 | XNCR | Xencor INC | Stock-Other | 2.53% | — | -3.58% | |
| 9 | XBI | Ss Spdr S&p Biotech ETF | ETF-Tech | 2.31% | -2.39% | EXIT | |
| 10 | ✓ | Relypsa INC | Stock-Other | 2.30% | — | -21.66% | |
| 11 | ✓ | Ignyta INC | Stock-Other | 1.81% | — | — | |
| 12 | ACRXUSD | Acelrx Pharmaceuticals INC | Stock-Other | 1.70% | — | — | |
| 13 | LION | Lionsgate Studios Corp. | Stock-Other | 1.54% | — | +1.66% | |
| 14 | GILD | Gilead Sciences INC | Stock-Healthcare | 1.45% | — | +1924.57% | |
| 15 | ANIP | Ani Pharmaceuticals INC | Stock-Other | 1.24% | — | +6.29% | |
| 16 | ✓ | Versartis INC | Stock-Other | 1.23% | — | -14.55% | |
| 17 | ✓ | Cempra INC | Stock-Other | 1.20% | — | — | |
| 18 | PFNXEUR | Pfenex INC | Stock-Other | 1.20% | — | +16.67% | |
| 19 | ✓ | Zs Pharma INC | Stock-Other | 1.16% | — | +93.69% | |
| 20 | EGRX | Eagle Pharmaceuticals INC | Stock-Other | 1.15% | — | +1827.90% | |
| 21 | ✓ | Stock-Other | 1.10% | — | — | ||
| 22 | QURE | uniQure N.V. | Stock-Other | 1.07% | — | -37.43% | |
| 23 | ✓ | Acadia Pharmaceuticals INC | Stock-Other | 1.05% | — | — | |
| 24 | ✓ | Stock-Other | 1.04% | — | +110.86% | ||
| 25 | ESPR | Esperion Therapeutics INC | Stock-Other | 1.00% | — | +195978.43% | |
| 26 | RDUSEUR | Radius Health INC | Stock-Other | 0.97% | — | +218.28% | |
| 27 | CSUUSD | Capital Senior Living CORP | Stock-Other | 0.96% | — | +5.87% | |
| 28 | ✓ | Assembly Biosciences INC | Stock-Other | 0.92% | — | — | |
| 29 | ZBH | Zimmer Biomet Holdings INC | Stock-Healthcare | 0.90% | — | -25.22% | |
| 30 | ✓ | Mylan N V | Stock-Other | 0.89% | — | +4091.17% | |
| 31 | ✓ | Thoratec CORP | Stock-Other | 0.89% | — | -18.50% | |
| 32 | HRTX | Heron Therapeutics INC | Stock-Other | 0.85% | — | — | |
| 33 | AFRM | Affirm Holdings, Inc. | Stock-Financials | 0.84% | — | +27.05% | |
| 34 | ✓ | Oncothyreon INC | Stock-Other | 0.76% | — | +261.83% | |
| 35 | ✓ | Bellicum Pharmaceuticals | Stock-Other | 0.72% | — | — | |
| 36 | PBYI | Puma Biotechnology INC | Stock-Other | 0.71% | — | — | |
| 37 | ✓ | Receptos, INC. | Stock-Other | 0.71% | — | -48.68% | |
| 38 | 2655787D | Blueprint Medicines CORP | Stock-Other | 0.65% | — | — | |
| 39 | ✓ | Anthera Pharmaceutcls INC | Stock-Other | 0.63% | — | -25.01% | |
| 40 | ✓ | Alliqua INC | Stock-Other | 0.62% | — | +71.30% | |
| 41 | ✓ | Shire PLC | Stock-Other | 0.59% | — | +33.33% | |
| 42 | SGMOQ | Sangamo Therapeutics INC | Stock-Other | 0.54% | — | — | |
| 43 | XLRN | Acceleron Pharma INC | Stock-Other | 0.53% | — | -17.86% | |
| 44 | ✓ | Neptune Technologies Bioreso | Stock-Other | 0.53% | — | -0.74% | |
| 45 | ✓ | Quotient LTD | Stock-Other | 0.52% | — | +2.10% | |
| 46 | ANIP 3 12-01-19 | Ani Pharmaceuticals INC | Stock-Other | 0.52% | — | — | |
| 47 | OTICEUR | Otonomy INC | Stock-Other | 0.52% | — | -23.52% | |
| 48 | CHRS | Coherus Oncology INC | Stock-Other | 0.46% | — | +203.34% | |
| 49 | BCRX | Biocryst Pharmaceuticals INC | Stock-Other | 0.43% | +0.94% | — | |
| 50 | SUPN 7.5 05-01-19 | Supernus Pharmaceuticals | Stock-Healthcare | 0.43% | — | -24.97% |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | SRPT | Sarepta Therapeutics INC | +3% | +12.01% | Add |
| 2 | GILD | Gilead Sciences INC | +1.4% | +1924.57% | Add |
| 3 | ✓ | Derma Sciences INC | +1.3% | +1.60% | Add |
| 4 | EGRX | Eagle Pharmaceuticals INC | +1.1% | +1827.90% | Add |
| 5 | ESPR | Esperion Therapeutics INC | +1% | +195978.43% | Add |
| 6 | ✓ | Mylan N V | +0.9% | +4091.17% | Add |
| 7 | RDUSEUR | Radius Health INC | +0.7% | +218.28% | Add |
| 8 | ✓ | Oncothyreon INC | +0.6% | +261.83% | Add |
| 9 | RTRXEUR | Retrophin INC | +0.5% | +4.88% | Add |
| 10 | ✓ | Zs Pharma INC | +0.5% | +93.69% | Add |
| 11 | NVROEUR | Nevro CORP | +0.5% | +43.43% | Add |
| 12 | ✓ | +0.5% | +110.86% | Add | |
| 13 | AFRM | Affirm Holdings, Inc. | +0.4% | +27.05% | Add |
| 14 | CLLS | Cellectis - Adr | +0.4% | +12000.00% | Add |
| 15 | XNCR | Xencor INC | +0.2% | -3.58% | Trim |
| 16 | PFNXEUR | Pfenex INC | +0.1% | +16.67% | Add |
| 17 | AM6 | Amicus Therapeutics INC | +0.1% | — | Unchanged |
| 18 | ✓ | Dyax CORP | 0% | -17.95% | Trim |
| 19 | INSM | Insmed INC | -0.5% | -51.21% | Trim |
| 20 | PTLAEUR | Portola Pharmaceuticals INC | -0.8% | -68.70% | Trim |
| 21 | ZBH | Zimmer Biomet Holdings INC | -0.8% | -25.22% | Trim |
| 22 | OTICEUR | Otonomy INC | -0.8% | -23.52% | Trim |
| 23 | ✓ | Receptos, INC. | -0.8% | -48.68% | Trim |
| 24 | QURE | uniQure N.V. | -0.9% | -37.43% | Trim |
| 25 | LION | Lionsgate Studios Corp. | -1% | +1.66% | Add |
| 26 | T8S | Tesaro INC | -1.4% | -14.62% | Trim |
| 27 | ✓ | Relypsa INC | -1.8% | -21.66% | Trim |
| 28 | NBIX | Neurocrine Biosciences INC | -2.1% | -12.21% | Trim |
| 29 | XBI | Ss Spdr S&p Biotech ETF | — | NEW | New buy |
| 30 | ✓ | Ignyta INC | — | NEW | New buy |
| 31 | ✓ | Bellicum Pharmaceuticals INC | — | EXIT | Sold out |
| 32 | ACAD | Acadia Pharmaceuticals INC | — | EXIT | Sold out |
| 33 | ✓ | — | NEW | New buy | |
| 34 | ✓ | Acadia Pharmaceuticals INC | — | NEW | New buy |
| 35 | ✓ | — | EXIT | Sold out | |
| 36 | ✓ | Assembly Biosciences INC | — | NEW | New buy |
| 37 | ✓ | — | EXIT | Sold out | |
| 38 | HRTX | Heron Therapeutics INC | — | NEW | New buy |
| 39 | ✓ | Bellicum Pharmaceuticals | — | NEW | New buy |
| 40 | PBYI | Puma Biotechnology INC | — | NEW | New buy |
| 41 | ✓ | Celladon CORP | — | EXIT | Sold out |
| 42 | 2655787D | Blueprint Medicines CORP | — | NEW | New buy |
| 43 | ✓ | Aegerion Pharmaceuticals INC | — | EXIT | Sold out |
| 44 | BIIB | Biogen INC | — | EXIT | Sold out |
| 45 | BCRX | Biocryst Pharmaceuticals INC | — | NEW | New buy |
| 46 | ✓ | Vital Therapies INC | — | NEW | New buy |
| 47 | IRWD | Ironwood Pharmaceuticals INC | — | NEW | New buy |
| 48 | ASMB | Assembly Biosciences, Inc. | — | EXIT | Sold out |
| 49 | SSO | Proshares Ultra S&p500 | — | NEW | New buy |
| 50 | ✓ | Ardelyx Inc | — | NEW | New buy |