CIK: 0001224962
Total reported value
$5.1B
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | AM6 | Amicus Therapeutics INC | Stock-Other | 12.21% | -1.62% | EXIT | |
| 2 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 11.55% | -0.67% | -27.57% | |
| 3 | RTRXEUR | Retrophin INC | Stock-Other | 5.19% | — | +43.50% | |
| 4 | T8S | Tesaro INC | Stock-Other | 4.36% | — | +10.75% | |
| 5 | ✓ | Relypsa INC | Stock-Other | 4.08% | — | +17.35% | |
| 6 | SRPT | Sarepta Therapeutics INC | Stock-Healthcare | 3.05% | — | -9.43% | |
| 7 | ✓ | Dyax CORP | Stock-Other | 2.83% | — | +17.55% | |
| 8 | LION | Lionsgate Studios Corp. | Stock-Other | 2.55% | — | -15.55% | |
| 9 | XNCR | Xencor INC | Stock-Other | 2.33% | — | +1.43% | |
| 10 | NVROEUR | Nevro CORP | Stock-Other | 2.07% | — | +215.50% | |
| 11 | ACRXUSD | Acelrx Pharmaceuticals INC | Stock-Other | 1.97% | — | — | |
| 12 | QURE | uniQure N.V. | Stock-Other | 1.96% | — | +430.66% | |
| 13 | ✓ | Bellicum Pharmaceuticals INC | Stock-Other | 1.88% | — | — | |
| 14 | ✓ | Versartis INC | Stock-Other | 1.88% | — | +66.08% | |
| 15 | ZBH | Zimmer Biomet Holdings INC | Stock-Healthcare | 1.65% | — | +17.33% | |
| 16 | ✓ | Cempra INC | Stock-Other | 1.53% | — | +131.31% | |
| 17 | ✓ | Receptos, INC. | Stock-Other | 1.52% | — | -59.23% | |
| 18 | ACAD | Acadia Pharmaceuticals INC | Stock-Healthcare | 1.52% | — | -45.10% | |
| 19 | ANIP | Ani Pharmaceuticals INC | Stock-Other | 1.50% | — | -1.51% | |
| 20 | OTICEUR | Otonomy INC | Stock-Other | 1.32% | — | +5.74% | |
| 21 | ✓ | Thoratec CORP | Stock-Other | 1.30% | — | -18.78% | |
| 22 | ✓ | Stock-Other | 1.27% | — | -40.00% | ||
| 23 | CSUUSD | Capital Senior Living CORP | Stock-Other | 1.22% | — | +142.00% | |
| 24 | ✓ | Stock-Other | 1.14% | — | +225.99% | ||
| 25 | PFNXEUR | Pfenex INC | Stock-Other | 1.07% | — | +114.11% | |
| 26 | PTLAEUR | Portola Pharmaceuticals INC | Stock-Other | 1.05% | — | +1320.00% | |
| 27 | XLRN | Acceleron Pharma INC | Stock-Other | 0.99% | — | +5.79% | |
| 28 | SGMOQ | Sangamo Therapeutics INC | Stock-Other | 0.97% | — | — | |
| 29 | INSM | Insmed INC | Stock-Healthcare | 0.95% | — | -14.58% | |
| 30 | ✓ | Neptune Technologies Bioreso | Stock-Other | 0.85% | — | — | |
| 31 | ✓ | Celladon CORP | Stock-Other | 0.85% | — | — | |
| 32 | ✓ | Quotient LTD | Stock-Other | 0.83% | — | +21.37% | |
| 33 | ✓ | Aegerion Pharmaceuticals INC | Stock-Other | 0.78% | — | — | |
| 34 | ✓ | Endologix INC | Stock-Other | 0.75% | — | +169.05% | |
| 35 | ANIP 3 12-01-19 | Ani Pharmaceuticals INC | Stock-Other | 0.67% | — | — | |
| 36 | ✓ | Zs Pharma INC | Stock-Other | 0.61% | — | — | |
| 37 | BIIB | Biogen INC | Stock-Healthcare | 0.60% | -0.39% | EXIT | |
| 38 | ✓ | Shire PLC | Stock-Other | 0.56% | — | +200.00% | |
| 39 | ✓ | Anthera Pharmaceutcls INC | Stock-Other | 0.56% | — | +218.62% | |
| 40 | ✓ | Vbi Vaccines INC | Stock-Other | 0.53% | — | — | |
| 41 | ✓ | Stock-Other | 0.52% | — | -5.43% | ||
| 42 | SUPN 7.5 05-01-19 | Supernus Pharmaceuticals | Stock-Healthcare | 0.52% | — | — | |
| 43 | 2GT | Applied Genetic Technologies | Stock-Other | 0.47% | — | — | |
| 44 | ✓ | Alliqua INC | Stock-Other | 0.45% | — | — | |
| 45 | ASMB | Assembly Biosciences, Inc. | Stock-Other | 0.44% | — | — | |
| 46 | ✓ | Tokai Pharmaceuticals INC | Stock-Other | 0.43% | — | -5.56% | |
| 47 | CPRX | Catalyst Pharmaceuticals INC | Stock-Healthcare | 0.40% | — | — | |
| 48 | ✓ | Medgenics Inc New | Stock-Other | 0.40% | — | +24.31% | |
| 49 | FPRX | Five Prime Therapeutics INC | Stock-Other | 0.40% | — | +44.36% | |
| 50 | AFRM | Affirm Holdings, Inc. | Stock-Financials | 0.39% | — | -19.88% |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | RTRXEUR | Retrophin INC | +3.2% | +43.50% | Add |
| 2 | AM6 | Amicus Therapeutics INC | +2.1% | — | Unchanged |
| 3 | NBIX | Neurocrine Biosciences INC | +1.9% | -27.57% | Trim |
| 4 | QURE | uniQure N.V. | +1.7% | +430.66% | Add |
| 5 | T8S | Tesaro INC | +1.6% | +10.75% | Add |
| 6 | NVROEUR | Nevro CORP | +1.5% | +215.50% | Add |
| 7 | ✓ | Cempra INC | +1% | +131.31% | Add |
| 8 | PTLAEUR | Portola Pharmaceuticals INC | +1% | +1320.00% | Add |
| 9 | ✓ | Relypsa INC | +0.9% | +17.35% | Add |
| 10 | PFNXEUR | Pfenex INC | +0.8% | +114.11% | Add |
| 11 | ✓ | +0.8% | +225.99% | Add | |
| 12 | CSUUSD | Capital Senior Living CORP | +0.7% | +142.00% | Add |
| 13 | ✓ | Dyax CORP | +0.7% | +17.55% | Add |
| 14 | ✓ | Anthera Pharmaceutcls INC | +0.5% | +218.62% | Add |
| 15 | ✓ | Endologix INC | +0.5% | +169.05% | Add |
| 16 | LION | Lionsgate Studios Corp. | +0.4% | -15.55% | Trim |
| 17 | ✓ | Shire PLC | +0.4% | +200.00% | Add |
| 18 | ✓ | Versartis INC | +0.2% | +66.08% | Add |
| 19 | MGNX | Macrogenics INC | -0.4% | -50.79% | Trim |
| 20 | CHRS | Coherus Oncology INC | -0.4% | -80.53% | Trim |
| 21 | ✓ | -0.5% | -40.00% | Trim | |
| 22 | VNDA | Vanda Pharmaceuticals INC | -0.7% | -71.43% | Trim |
| 23 | SRPT | Sarepta Therapeutics INC | -0.9% | -9.43% | Trim |
| 24 | ESPR | Esperion Therapeutics INC | -1% | -99.97% | Trim |
| 25 | CELG | Celgene CORP | -1.1% | -79.55% | Trim |
| 26 | ACAD | Acadia Pharmaceuticals INC | -1.4% | -45.10% | Trim |
| 27 | ✓ | Receptos, INC. | -1.5% | -59.23% | Trim |
| 28 | ✓ | Taro Pharmaceutical Inds LTD | -1.5% | -78.20% | Trim |
| 29 | ACRXUSD | Acelrx Pharmaceuticals INC | -1.7% | — | Unchanged |
| 30 | PTCT | Ptc Therapeutics INC | — | EXIT | Sold out |
| 31 | VRTX | Vertex Pharmaceuticals INC | — | EXIT | Sold out |
| 32 | ✓ | Ophthotech Corporation | — | EXIT | Sold out |
| 33 | ✓ | Allergan INC | — | EXIT | Sold out |
| 34 | BDX | Becton Dickinson And Co | — | EXIT | Sold out |
| 35 | ✓ | Celladon CORP | — | NEW | New buy |
| 36 | ✓ | Aegerion Pharmaceuticals INC | — | NEW | New buy |
| 37 | ZFGNUSD | Zafgen INC | — | EXIT | Sold out |
| 38 | EPZMEUR | Epizyme INC | — | EXIT | Sold out |
| 39 | ✓ | Zs Pharma INC | — | NEW | New buy |
| 40 | BIIB | Biogen INC | — | NEW | New buy |
| 41 | BDSIUSD | Biodelivery Sciences Intl | — | EXIT | Sold out |
| 42 | ✓ | Vbi Vaccines INC | — | NEW | New buy |
| 43 | HRTX | Heron Therapeutics INC | — | EXIT | Sold out |
| 44 | SUPN 7.5 05-01-19 | Supernus Pharmaceuticals | — | NEW | New buy |
| 45 | ASMB | Assembly Biosciences, Inc. | — | NEW | New buy |
| 46 | CPRX | Catalyst Pharmaceuticals INC | — | NEW | New buy |
| 47 | PRTA | Prothena Corporation plc | — | EXIT | Sold out |
| 48 | ALDR1EUR | Alder Biopharmaceuticals INC | — | NEW | New buy |
| 49 | ✓ | — | EXIT | Sold out | |
| 50 | QDELUSD | Quidelortho CORP | — | EXIT | Sold out |