DAFNA Capital Management LLC — Q1 2025 13F Holdings

Name: DAFNA Capital Management LLC — 13F Holdings, Q1 2025
Creator: AlphaSMO
License: https://www.sec.gov/forms

CIK: 0001389933

Total reported value

$439.6M

← Back to latest quarter

Full holdings list this quarter

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	XBI	Ss Spdr S&p Biotech ETF	ETF-Tech	9.30%	—	+1.76%
2	STXS	Stereotaxis INC	Stock-Other	6.83%	-1.58%	—
3	RVMD	Revolution Medicines INC	Stock-Healthcare	6.58%	+1.67%	+3.96%
4	✓	Merus N V	Stock-Other	5.51%	—	+2.21%
5	ATRC	Atricure INC	Stock-Other	5.42%	-1.61%	-7.70%
6	CYTK	Cytokinetics INC	Stock-Healthcare	4.54%	-2.22%	—
7	2655787D	Blueprint Medicines CORP	Stock-Other	3.82%	—	+1.67%
8	IBB	Ishares Biotechnology ETF	ETF-Tech	3.72%	-0.28%	—
9	AXGN	Axogen INC	Stock-Other	3.57%	-1.74%	-19.61%
10	ASND	Ascendis Pharma A/S	Stock-Other	3.55%	-0.19%	-22.21%
11	IDYA	Ideaya Biosciences INC	Stock-Other	2.74%	-0.46%	+18.14%
12	XENE	Xenon Pharmaceuticals INC	Stock-Other	2.60%	+0.32%	—
13	4XC1	Kalvista Pharmaceuticals INC	Stock-Other	2.46%	—	-7.31%
14	NBIX	Neurocrine Biosciences INC	Stock-Healthcare	2.25%	-0.21%	—
15	SNDX	Syndax Pharmaceuticals INC	Stock-Other	1.90%	-0.20%	+0.46%
16	DAWNGBX	Day One Biopharmaceuticals I	Stock-Other	1.64%	+2.61%	—
17	TNDM	Tandem Diabetes Care INC	Stock-Other	1.60%	-0.26%	+31.81%
18	URGN	UroGen Pharma Ltd.	Stock-Other	1.54%	—	—
19	BHVN	Biohaven Ltd.	Stock-Other	1.50%	-0.87%	—
20	MLYS	Mineralys Therapeutics INC	Stock-Other	1.39%	—	+111.06%
21	RCUS	Arcus Biosciences INC	Stock-Other	1.39%	-0.21%	+145.90%
22	ASND 2.25 04-01-28	Ascendis Pharma A/s	Stock-Other	1.34%	—	—
23	DXCM	Dexcom INC	Stock-Healthcare	1.27%	—	—
24	BCRX	Biocryst Pharmaceuticals INC	Stock-Other	1.19%	+0.17%	-16.30%
25	EWTX	Edgewise Therapeutics INC	Stock-Other	1.14%	—	-2.14%
26	LKFT	Lakefront Biotherapeutic-adr	Stock-Other	0.93%	—	—
27	INGN	Inogen INC	Stock-Other	0.93%	—	+119.39%
28	PODD	Insulet CORP	Stock-Healthcare	0.89%	—	-4.03%
29	ALKS	Alkermes plc	Stock-Healthcare	0.88%	+0.27%	-21.96%
30	KURA	Kura Oncology INC	Stock-Other	0.87%	—	+3.35%
31	STOK	Stoke Therapeutics INC	Stock-Other	0.84%	+0.17%	+159.50%
32	IMVT	Immunovant INC	Stock-Other	0.82%	—	+57.41%
33	BCAX	Bicara Therapeutics INC	Stock-Other	0.78%	+0.89%	+100.95%
34	ARAY	Accuray INC	Stock-Other	0.62%	—	—
35	TSVT*	2seventy Bio INC	Stock-Other	0.60%	—	—
36	✓	Proqr Thrapeutics N V	Stock-Other	0.59%	-0.16%	—
37	CMPS	Compass Pathways PLC	Stock-Other	0.58%	+1.74%	+192.36%
38	ALLO	Allogene Therapeutics INC	Stock-Other	0.57%	+0.32%	+11.29%
39	TELA	Tela Bio INC	Stock-Other	0.50%	-0.20%	—
40	ALGN	Align Technology INC	Stock-Healthcare	0.50%	—	+100.00%
41	DNLI	Denali Therapeutics INC	Stock-Other	0.49%	+0.17%	—
42	CATBUSD	Astria Therapeutics INC	Stock-Other	0.48%	-0.93%	EXIT
43	VKTX	Viking Therapeutics INC	Stock-Healthcare	0.44%	—	—
44	RGLS	Regulus Therapeutics INC	Stock-Other	0.42%	—	-3.20%
45	BWAY	Brainsway Ltd-adr	Stock-Other	0.42%	—	-18.98%
46	ORIC	Oric Pharmaceuticals INC	Stock-Other	0.38%	—	—
47	KROS	Keros Therapeutics INC	Stock-Other	0.38%	—	—
48	LXEO	Lexeo Therapeutics INC	Stock-Other	0.37%	-0.30%	-3.82%
49	2662247D	Iteos Therapeutics INC	Stock-Other	0.36%	—	+13.27%
50	PVLA	Palvella Therapeutics INC	Stock-Other	0.34%	—	-39.33%

1–50 of 83

Holding changes this quarter

Position changes disclosed by DAFNA Capital Management LLC for the quarter ending Q1 2025, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	RVMD	Revolution Medicines INC	+5.2%	+3.96%	Add
2	✓	Merus N V	+4.8%	+2.21%	Add
3	ATRC	Atricure INC	+3.9%	-7.70%	Add
4	ASND	Ascendis Pharma A/S	+3.4%	-22.21%	Add
5	IBB	Ishares Biotechnology ETF	+2.3%	—	Add
6	4XC1	Kalvista Pharmaceuticals INC	+2.2%	-7.31%	Add
7	SNDX	Syndax Pharmaceuticals INC	+1.4%	+0.46%	Add
8	2655787D	Blueprint Medicines CORP	—	+1.67%	Trim
9	DXCM	Dexcom INC	-0.6%	—	Add
10	TORCEUR	Adicet Bio INC	-0.7%	—	Add
11	✓	Proqr Thrapeutics N V	-0.9%	—	Add
12	SG7	Sage Therapeutics INC	-1.8%	—	Trim
13	STXS	Stereotaxis INC	-20.8%	—	Unchanged
14	XBI	Ss Spdr S&p Biotech ETF	—	NEW	New buy
15	FATE	Fate Therapeutics INC	—	EXIT	Sold out
16	DRNAUSD	Dicerna Pharmaceuticals INC	—	EXIT	Sold out
17	CYTK	Cytokinetics INC	—	NEW	New buy
18	AXGN	Axogen INC	—	NEW	New buy
19	TBPH	Theravance Biopharma, Inc.	—	EXIT	Sold out
20	MORFUSD	Morphic Holding INC	—	EXIT	Sold out
21	✓	Translate Bio INC	—	EXIT	Sold out
22	BHVN	Biohaven Ltd.	—	EXIT	Sold out
23	AFRM	Affirm Holdings, Inc.	—	EXIT	Sold out
24	ARNAEUR	Arena Pharmaceuticals INC	—	EXIT	Sold out
25	NRIX	Nurix Therapeutics INC	—	EXIT	Sold out
26	CSIIEUR	Cardiovascular Systems INC	—	EXIT	Sold out
27	✓	F-star Therapeutics INC	—	EXIT	Sold out
28	✓		—	EXIT	Sold out
29	DAWNGBX	Day One Biopharmaceuticals I	—	NEW	New buy
30	TNDM	Tandem Diabetes Care INC	—	NEW	New buy
31	URGN	UroGen Pharma Ltd.	—	NEW	New buy
32	OTICEUR	Otonomy INC	—	EXIT	Sold out
33	BHVN	Biohaven Ltd.	—	NEW	New buy
34	✓	Luminex CORP	—	EXIT	Sold out
35	MLYS	Mineralys Therapeutics INC	—	NEW	New buy
36	ASND 2.25 04-01-28	Ascendis Pharma A/s	—	NEW	New buy
37	AERIEUR	Aerie Pharmaceuticals INC	—	EXIT	Sold out
38	CARAEUR	Cara Therapeutics INC	—	EXIT	Sold out
39	BCRX	Biocryst Pharmaceuticals INC	—	NEW	New buy
40	STIM	Neuronetics INC	—	EXIT	Sold out
41	EWTX	Edgewise Therapeutics INC	—	NEW	New buy
42	TPB	Turning Point Brands, Inc.	—	EXIT	Sold out
43	RDUS 3 09-01-24	Radius Health INC	—	EXIT	Sold out
44	✓		—	EXIT	Sold out
45	MREO	Mereo Biopharma Group Pl-adr	—	EXIT	Sold out
46	RDHLGBP	Redhill Biopharma Ltd-sp Adr	—	EXIT	Sold out
47	PODD	Insulet CORP	—	NEW	New buy
48	ALKS	Alkermes plc	—	NEW	New buy
49	✓	Fs Development CORP Ii	—	EXIT	Sold out
50	STOK	Stoke Therapeutics INC	—	NEW	New buy