申报总市值
US$1.7亿
申报季度: 2026-03-31 · 持股只数: 88
Knott David M Jr在最新一期 13F 报告中披露了 88 项持股，申报期为 2026-03-31，总持股市值约为 US$1.7亿，季度换手率为 54.5%。
加仓 GOOG
0.0% -US$245.9万
加仓 SNDX
+1.7% US$113.9万
加仓 AGIO
+417.0% US$265.8万
加仓 ALKS
+26.3% US$158.5万
加仓 TGTX
+100.0% US$164.8万
加仓 PTGX
-13.7% US$26.4万
仅显示前 85 大持股（共 88 只）
| # | 代码 | 标的名称 | 资产子类别 | 占比 | 占比变动 | 持仓量变化 | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | GOOG | Alphabet Inc-cl C | 股票-通信服务 | 15.61% | +2.33% | — | |
| 2 | APO | Apollo Global Management INC | 股票-金融 | 14.92% | -0.16% | — | |
| 3 | SNDX | Syndax Pharmaceuticals INC | 股票-其他 | 5.87% | +1.83% | +1.69% | |
| 4 | BBIO | Bridgebio Pharma INC | 股票-医疗保健 | 3.98% | — | +5.88% | |
| 5 | PTGX | Protagonist Therapeutics INC | 股票-其他 | 3.95% | +1.00% | -13.70% | |
| 6 | XERS | Xeris Biopharma Holdings INC | 股票-其他 | 3.66% | +0.13% | +9.28% | |
| 7 | JPM | Jpmorgan Chase & Co | 股票-金融 | 3.41% | +0.50% | — | |
| 8 | IOVA | Iovance Biotherapeutics INC | 股票-其他 | 3.34% | +3.34% | NEW | |
| 9 | ✓ | LPL Financial Holdings Inc. | 股票-其他 | 2.95% | +2.95% | NEW | |
| 10 | JAAA | Janus Henderson Aaa Clo ETF | ETF-其他 | 2.80% | — | — | |
| 11 | ALKS | Alkermes plc | 股票-医疗保健 | 2.53% | +1.30% | +26.32% | |
| 12 | TVTX | Travere Therapeutics INC | 股票-其他 | 2.49% | -0.80% | -24.39% | |
| 13 | COGT | Cogent Biosciences INC | 股票-其他 | 2.38% | +0.70% | +1.96% | |
| 14 | VRDN | Viridian Therapeutics INC | 股票-其他 | 2.11% | +0.02% | +24.83% | |
| 15 | AGIO | Agios Pharmaceuticals INC | 股票-其他 | 1.87% | +1.64% | +416.99% | |
| 16 | RLMD | Relmada Therapeutics INC | 股票-其他 | 1.82% | +1.82% | NEW | |
| 17 | TGTX | Tg Therapeutics INC | 股票-医疗保健 | 1.78% | +1.16% | +100.00% | |
| 18 | CPRX | Catalyst Pharmaceuticals INC | 股票-医疗保健 | 1.77% | -0.27% | -36.51% | |
| 19 | ✓ | Arcellx INC Common Stock | 股票-其他 | 1.33% | +0.55% | -24.39% | |
| 20 | XBI | Ss Spdr S&p Biotech ETF | ETF-科技型 | 1.14% | +0.41% | +15.38% | |
| 21 | AB | Alliancebernstein Holding LP | 股票-其他 | 1.07% | — | — | |
| 22 | RCUS | Arcus Biosciences INC | 股票-其他 | 1.04% | -0.30% | -32.99% | |
| 23 | DCGO | Docgo INC | 股票-其他 | 1.00% | -0.09% | — | |
| 24 | HELP | Cybin INC | 股票-其他 | 1.00% | -0.08% | +22.73% | |
| 25 | CYTK | Cytokinetics INC | 股票-医疗保健 | 0.93% | -0.07% | -30.46% | |
| 26 | 260 | Centessa Pharmaceuticals-adr | 股票-其他 | 0.92% | +0.87% | +875.00% | |
| 27 | ATRC | Atricure INC | 股票-其他 | 0.87% | -0.07% | — | |
| 28 | ARDX | Ardelyx INC | 股票-其他 | 0.74% | +0.74% | NEW | |
| 29 | CLOZ | Eldridge Bbb-b Clo ETF | ETF-其他 | 0.73% | — | — | |
| 30 | JNJ | Johnson & Johnson | 股票-医疗保健 | 0.72% | — | -28.89% | |
| 31 | RZLT | Rezolute INC | 股票-其他 | 0.67% | +0.30% | +8.82% | |
| 32 | OBIO | Orchestra Biomed Holdings In | 股票-其他 | 0.64% | — | +1.46% | |
| 33 | MDGL | Madrigal Pharmaceuticals INC | 股票-医疗保健 | 0.62% | — | — | |
| 34 | VERA | Vera Therapeutics INC | 股票-其他 | 0.62% | +0.01% | — | |
| 35 | ✓ | Connect Biopharma Hldgs LTD | 股票-其他 | 0.60% | +0.34% | +93.92% | |
| 36 | IBB | Ishares Biotechnology ETF | ETF-科技型 | 0.55% | — | — | |
| 37 | PFE | Pfizer INC | 股票-医疗保健 | 0.54% | — | — | |
| 38 | BMY | Bristol-myers Squibb Co | 股票-医疗保健 | 0.49% | -0.06% | -38.08% | |
| 39 | CNQ | Canadian Natural Resources | 股票-能源 | 0.49% | +0.23% | — | |
| 40 | BIIB | Biogen INC | 股票-医疗保健 | 0.44% | -0.05% | -33.33% | |
| 41 | RARE | Ultragenyx Pharmaceutical In | 股票-其他 | 0.41% | +0.20% | +65.30% | |
| 42 | AAPL | Apple INC | 股票-科技 | 0.38% | — | — | |
| 43 | MSFT | Microsoft CORP | 股票-科技 | 0.35% | — | — | |
| 44 | VSTM | Verastem INC | 股票-其他 | 0.33% | +0.33% | NEW | |
| 45 | ADMA | Adma Biologics INC | 股票-医疗保健 | 0.32% | -0.19% | — | |
| 46 | IBM | Intl Business Machines CORP | 股票-科技 | 0.31% | — | — | |
| 47 | ✓ | Biohaven Pharmaceutical Holding Co. Ltd | 股票-其他 | 0.31% | +0.31% | NEW | |
| 48 | PTHS | Pelthos Therapeutics INC | 股票-其他 | 0.26% | — | +9.29% | |
| 49 | KURA | Kura Oncology INC | 股票-其他 | 0.26% | — | +34.58% | |
| 50 | ✓ | Evolus INC | 股票-其他 | 0.24% | -0.07% | — |
Q3 2026表现
+11.2%
近4个季度表现
+62.8%
基于可获取价格的持仓（占申报价值的86%）计算
| 季度 | 持股只数 | 总市值 | 稳定性 | 主要持股 |
|---|---|---|---|---|
| 2026-03-31 | 88 | US$1.7亿 | 54 | |
| 2025-12-31 | 91 | US$2.2亿 | 44 | |
| 2025-09-30 | 92 | US$2.5亿 | 50 | |
| 2025-06-30 | 89 | US$2.2亿 | 0 | |
| 2025-03-31 | 88 | US$2.1亿 | 0 | |
| 2024-12-31 | 93 | US$2.8亿 | 0 | |
| 2024-09-30 | 99 | US$2.8亿 | 0 | |
| 2024-06-30 | 106 | US$2.5亿 | 0 | |
| 2024-03-31 | 114 | US$2.8亿 | 0 | |
| 2023-12-31 | 119 | US$2.6亿 | 0 | |
| 2023-09-30 | 135 | US$2.6亿 | 0 | |
| 2023-06-30 | 153 | US$2.5亿 | 0 | |
| 2023-03-31 | 154 | US$2.5亿 | 0 | |
| 2022-12-31 | 182 | US$2.6亿 | 0 | |
| 2022-09-30 | 192 | US$2.4亿 | 0 | |
| 2022-06-30 | 197 | US$2.4亿 | 0 | |
| 2022-03-31 | 180 | US$3.1亿 | 0 | |
| 2021-12-31 | 170 | US$2.9亿 | 0 |
Knott David M Jr 在 2026-03-31 最显著的持仓异动： 清仓: Calumet INC (CLMT); 新建仓: Iovance Biotherapeutics INC (IOVA); 新建仓: LPL Financial Holdings Inc.; 新建仓: Relmada Therapeutics INC (RLMD); 清仓: Tectonic Therapeutic INC (TECX).
| # | 代码 | 标的名称 | 占比变动 | 持仓量变化 | 异动类型 |
|---|---|---|---|---|---|
| 1 | GOOG | Alphabet Inc-cl C | +2.3% | — | 不变 |
| 2 | SNDX | Syndax Pharmaceuticals INC | +1.8% | +1.69% | 加仓 |
| 3 | AGIO | Agios Pharmaceuticals INC | +1.6% | +416.99% | 加仓 |
| 4 | ALKS | Alkermes plc | +1.3% | +26.32% | 加仓 |
| 5 | TGTX | Tg Therapeutics INC | +1.2% | +100.00% | 加仓 |
| 6 | PTGX | Protagonist Therapeutics INC | +1% | -13.70% | 减仓 |
| 7 | 260 | Centessa Pharmaceuticals-adr | +0.9% | +875.00% | 加仓 |
| 8 | COGT | Cogent Biosciences INC | +0.7% | +1.96% | 加仓 |
| 9 | ✓ | Arcellx INC Common Stock | +0.6% | -24.39% | 减仓 |
| 10 | JPM | Jpmorgan Chase & Co | +0.5% | — | 不变 |
| 11 | XBI | Ss Spdr S&p Biotech ETF | +0.4% | +15.38% | 加仓 |
| 12 | ✓ | Connect Biopharma Hldgs LTD | +0.3% | +93.92% | 加仓 |
| 13 | RZLT | Rezolute INC | +0.3% | +8.82% | 加仓 |
| 14 | CNQ | Canadian Natural Resources | +0.2% | — | 不变 |
| 15 | RARE | Ultragenyx Pharmaceutical In | +0.2% | +65.30% | 加仓 |
| 16 | XERS | Xeris Biopharma Holdings INC | +0.1% | +9.28% | 加仓 |
| 17 | VRDN | Viridian Therapeutics INC | 0% | +24.83% | 加仓 |
| 18 | VERA | Vera Therapeutics INC | 0% | — | 不变 |
| 19 | BIIB | Biogen INC | -0.1% | -33.33% | 减仓 |
| 20 | BMY | Bristol-myers Squibb Co | -0.1% | -38.08% | 减仓 |
| 21 | CYTK | Cytokinetics INC | -0.1% | -30.46% | 减仓 |
| 22 | ATRC | Atricure INC | -0.1% | — | 不变 |
| 23 | ✓ | Evolus INC | -0.1% | — | 不变 |
| 24 | HELP | Cybin INC | -0.1% | +22.73% | 加仓 |
| 25 | DCGO | Docgo INC | -0.1% | — | 不变 |
| 26 | APO | Apollo Global Management INC | -0.2% | — | 不变 |
| 27 | ADMA | Adma Biologics INC | -0.2% | — | 不变 |
| 28 | SLDB | Solid Biosciences INC | -0.2% | -70.98% | 减仓 |
| 29 | LENZ | Lenz Therapeutics INC | -0.2% | -37.22% | 减仓 |
| 30 | CPRX | Catalyst Pharmaceuticals INC | -0.3% | -36.51% | 减仓 |
| 31 | RCUS | Arcus Biosciences INC | -0.3% | -32.99% | 减仓 |
| 32 | WVE | Wave Life Sciences Ltd. | -0.5% | -55.56% | 减仓 |
| 33 | TVTX | Travere Therapeutics INC | -0.8% | -24.39% | 减仓 |
| 34 | CLMT | Calumet INC | — | EXIT | 清仓 |
| 35 | IOVA | Iovance Biotherapeutics INC | — | NEW | 新建仓 |
| 36 | ✓ | LPL Financial Holdings Inc. | — | NEW | 新建仓 |
| 37 | RLMD | Relmada Therapeutics INC | — | NEW | 新建仓 |
| 38 | TECX | Tectonic Therapeutic INC | — | EXIT | 清仓 |
| 39 | BHVN | Biohaven Ltd. | — | EXIT | 清仓 |
| 40 | ARDX | Ardelyx INC | — | NEW | 新建仓 |
| 41 | NKTR | Nektar Therapeutics | — | EXIT | 清仓 |
| 42 | SRRK | Scholar Rock Holding CORP | — | EXIT | 清仓 |
| 43 | VSTM | Verastem INC | — | NEW | 新建仓 |
| 44 | ✓ | Biohaven Pharmaceutical Holding Co. Ltd | — | NEW | 新建仓 |
| 45 | XENE | Xenon Pharmaceuticals INC | — | EXIT | 清仓 |
| 46 | MRSN | Mersana Therapeutics INC | — | EXIT | 清仓 |
| 47 | FATE | Fate Therapeutics INC | — | EXIT | 清仓 |
| 48 | CGEM | Cullinan Therapeutics INC | — | NEW | 新建仓 |
| 49 | RAIN | Rain Enhancement Techno-cl A | — | NEW | 新建仓 |
| 50 | DAWNGBX | Day One Biopharmaceuticals I | — | EXIT | 清仓 |