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New Leaf Venture Partners, L.L.C.
Concentrated strategyQuality / disciplined sizing
Total reported value
$43.0M
Reporting period: 2025-09-30 · Number of holdings: 7
New Leaf Venture Partners, L.L.C. disclosed 7 holdings in its latest 13F filing for the period ending 2025-09-30, with total reported value of $43.0M and a quarterly turnover rate of 29.7%.
Personality snowflake
- Concentration
- 100
- Portfolio Stability
- 29.73
- Momentum/Contrarian
- 50
- Sector conviction
- 0
- Diversification
- 14
- Sizing Uniformity
- 89.53
Recent moves
Trim EWTX
0.0% -$6.0M
Add ARVN
0.0% $2.4M
Add COGT
0.0% $2.1M
Add CRNX
0.0% $1.1M
Add ALEC
0.0% $587.5K
Trim 75120L100
0.0% -$498.5K
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | EWTX | Edgewise Therapeutics INC | Stock-Other | 38.82% | -11.65% | — | |
| 2 | ARVN | Arvinas INC | Stock-Other | 31.38% | +6.59% | — | |
| 3 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 13.64% | +3.11% | — | |
| 4 | COGT | Cogent Biosciences INC | Stock-Other | 8.37% | +5.02% | — | |
| 5 | ✓ | Rallybio CORP | Stock-Other | 3.83% | -0.95% | — | |
| 6 | ALEC | Alector INC | Stock-Other | 2.33% | +1.40% | — | |
| 7 | ✓ | Passage Bio INC | Stock-Other | 1.63% | -0.33% | -96.50% |
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2025-09-30 | 7 | $43.0M | 30 | |
| 2025-06-30 | 8 | $52.9M | 0 | |
| 2025-03-31 | 9 | $44.9M | 100 | |
| 2024-12-31 | 9 | $74.8M | 0 | |
| 2024-09-30 | 10 | $97.3M | 0 | |
| 2024-06-30 | 10 | $82.2M | 0 | |
| 2024-03-31 | 11 | $114.3M | 0 | |
| 2023-12-31 | 12 | $124.2M | 0 | |
| 2023-09-30 | 12 | $77.9M | 0 | |
| 2023-06-30 | 14 | $116.4M | 0 | |
| 2023-03-31 | 17 | $121.0M | 0 | |
| 2022-12-31 | 17 | $138.1M | 0 | |
| 2022-09-30 | 19 | $168.5M | 0 | |
| 2022-06-30 | 21 | $154.4M | 0 | |
| 2022-03-31 | 21 | $202.9M | 0 | |
| 2021-12-31 | 22 | $276.0M | 0 | |
| 2021-09-30 | 22 | $346.7M | 0 | |
| 2021-06-30 | 19 | $389.6M | 0 | |
| 2021-03-31 | 18 | $429.7M | 100 | |
| 2020-12-31 | 17 | $432.8M | 59 | |
| 2020-09-30 | 18 | $248.2M | 37 | |
| 2020-06-30 | 20 | $348.5M | 34 | |
| 2020-03-31 | 20 | $334.3M | 54 | |
| 2019-12-31 | 19 | $460.3M | 44 | |
| 2019-09-30 | 19 | $330.6M | 22 | |
| 2019-06-30 | 21 | $373.1M | 21 | |
| 2019-03-31 | 20 | $364.9M | 48 | |
| 2018-12-31 | 20 | $364.3M | 41 | |
| 2018-09-30 | 20 | $549.6M | 42 | |
| 2018-06-30 | 15 | $414.3M | 90 | |
| 2018-03-31 | 14 | $185.2M | 46 | |
| 2017-12-31 | 16 | $213.8M | 38 | |
| 2017-09-30 | 16 | $215.5M | 76 | |
| 2017-06-30 | 15 | $142.4M | 42 | |
| 2017-03-31 | 16 | $195.2M | 59 | |
| 2016-12-31 | 15 | $139.6M | 37 | |
| 2016-09-30 | 14 | $138.9M | 25 | |
| 2016-06-30 | 14 | $116.2M | 35 | |
| 2016-03-31 | 13 | $110.5M | 50 | |
| 2015-12-31 | 10 | $149.4M | 75 | |
| 2015-09-30 | 13 | $115.3M | 40 | |
| 2015-06-30 | 14 | $150.9M | 79 | |
| 2015-03-31 | 13 | $147.3M | 63 | |
| 2014-12-31 | 13 | $205.5M | 0 |
Holding changes this quarter
New Leaf Venture Partners, L.L.C.'s most significant position changes for 2025-09-30: Sold out: Rocket Pharmaceuticals INC (RCKT); Sold out: Iterum Therapeutics PLC; Trim: Passage Bio INC — shares -96.50%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ARVN | Arvinas INC | +6.6% | — | Unchanged |
| 2 | COGT | Cogent Biosciences INC | +5% | — | Unchanged |
| 3 | CRNX | Crinetics Pharmaceuticals In | +3.1% | — | Unchanged |
| 4 | ALEC | Alector INC | +1.4% | — | Unchanged |
| 5 | ✓ | Passage Bio INC | -0.3% | -96.50% | Trim |
| 6 | ✓ | Rallybio CORP | -1% | — | Unchanged |
| 7 | EWTX | Edgewise Therapeutics INC | -11.7% | — | Unchanged |
| 8 | RCKT | Rocket Pharmaceuticals INC | — | EXIT | Sold out |
| 9 | ✓ | Iterum Therapeutics PLC | — | EXIT | Sold out |
FAQ
What is New Leaf Venture Partners, L.L.C. and what type of investor is it?
New Leaf Venture Partners, L.L.C. is a investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2025-09-30), the firm manages a tracked equity portfolio valued at approximately $43.0M, spread across 7 disclosed positions.
What are New Leaf Venture Partners, L.L.C.'s largest equity positions?
Based on the latest 13F filing, New Leaf Venture Partners, L.L.C.'s top holdings by market value are:
1. Edgewise Therapeutics INC (EWTX) — $16.7M (38.8%)
2. Arvinas INC (ARVN) — $13.5M (31.4%)
3. Crinetics Pharmaceuticals In (CRNX) — $5.9M (13.6%)
4. Cogent Biosciences INC (COGT) — $3.6M (8.4%)
5. Rallybio CORP — $1.6M (3.8%)
What changes did New Leaf Venture Partners, L.L.C. make in its most recent portfolio filing?
In the latest quarter, New Leaf Venture Partners, L.L.C. took a more defensive posture — trimming 1 positions and completely exiting 2 holdings. The largest of these moves: Sold out: Rocket Pharmaceuticals INC (RCKT); Sold out: Iterum Therapeutics PLC; Trim: Passage Bio INC — shares -96.50%
What sectors does New Leaf Venture Partners, L.L.C. focus on?
Sector breakdown data is not yet available for New Leaf Venture Partners, L.L.C.. Check back after the next 13F processing cycle.