DC

DAFNA Capital Management LLC

Diversified strategySector-focusedMomentum follower

Total reported value

$439.6M

Reporting period: 2026-03-31 · Number of holdings: 83

DAFNA Capital Management LLC disclosed 83 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $439.6M and a quarterly turnover rate of 29.7%.

Personality snowflake

Concentration
17.18
Portfolio Stability
29.68
Momentum/Contrarian
100
Sector conviction
100
Diversification
100
Sizing Uniformity
83.88

Recent moves

  • Add DAWNGBX

    -2.1%　$11.7M

  • Trim CYTK

    -41.4%　-$9.2M

  • Add NKTR

    +120.2%　$8.7M

  • Add CMPS

    +198.2%　$7.8M

  • Trim AXGN

    -47.6%　-$7.3M

  • Add RVMD

    -3.9%　$8.3M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

#TickerIssuerAsset SubclassWeightWeight ChangeShares Change4Q Trend
1RVMDRevolution Medicines INCStock-Healthcare12.85%+1.67%-3.94%
2XBISs Spdr S&p Biotech ETFETF-Tech9.25%—-5.35%
3STXSStereotaxis INCStock-Other5.73%-1.58%—
4DAWNGBXDay One Biopharmaceuticals IStock-Other4.77%+2.61%-2.07%
5ATRCAtricure INCStock-Other3.88%-1.61%—
6IDYAIdeaya Biosciences INCStock-Other3.61%-0.46%-5.92%
7XENEXenon Pharmaceuticals INCStock-Other3.32%+0.32%-12.91%
8CYTKCytokinetics INCStock-Healthcare3.26%-2.22%-41.38%
9CMPSCompass Pathways PLCStock-Other3.04%+1.74%+198.24%
10NKTRNektar TherapeuticsStock-Other2.70%+1.96%+120.24%
11IBBIshares Biotechnology ETFETF-Tech2.39%-0.28%-8.81%
12RCUSArcus Biosciences INCStock-Other2.18%-0.21%+2.90%
13NBIXNeurocrine Biosciences INCStock-Healthcare2.12%-0.21%—
14LRMRLarimar Therapeutics INCStock-Other2.08%+1.25%+116.06%
15BCAXBicara Therapeutics INCStock-Other1.91%+0.89%+61.22%
16AXGNAxogen INCStock-Other1.88%-1.74%-47.58%
17BHVNBiohaven Ltd.Stock-Other1.63%-0.87%-11.46%
18TNDMTandem Diabetes Care INCStock-Other1.55%-0.26%—
19DNLIDenali Therapeutics INCStock-Other1.39%+0.17%—
20ASND 2.25 04-01-28Ascendis Pharma A/sStock-Other1.35%——
21IPSCCentury Therapeutics INCStock-Other1.25%+0.60%-12.86%
22DXCMDexcom INCStock-Healthcare1.23%—-2.27%
234XC1Kalvista Pharmaceuticals INCStock-Other1.22%—-25.06%
24ASNDAscendis Pharma A/SStock-Other1.21%-0.19%-17.75%
25MBXMbx Biosciences INCStock-Other1.19%—+6.17%
26INGNInogen INCStock-Other1.19%—+2.19%
27SNDXSyndax Pharmaceuticals INCStock-Other1.16%-0.20%-21.77%
28ALKSAlkermes plcStock-Healthcare1.12%+0.27%+7.09%
29STOKStoke Therapeutics INCStock-Other0.97%+0.17%+20.21%
30BCRXBiocryst Pharmaceuticals INCStock-Other0.93%+0.17%+2.87%
31LKFTLakefront Biotherapeutic-adrStock-Other0.89%——
32IMVTImmunovant INCStock-Other0.85%——
33EWTXEdgewise Therapeutics INCStock-Other0.80%—-29.74%
34MPLTMaplight Therapeutics INCStock-Other0.79%+0.20%+18.95%
35ALLOAllogene Therapeutics INCStock-Other0.76%+0.32%-0.72%
36PRCTProcept Biorobotics CORPStock-Other0.68%-0.20%—
37ALGNAlign Technology INCStock-Healthcare0.58%—-6.25%
38✓ Proqr Thrapeutics N VStock-Other0.58%-0.16%—
39HELPCybin INCStock-Other0.54%-0.32%+9.53%
40RAPPRapport Therapeutics INCStock-Other0.53%——
41PODDInsulet CORPStock-Healthcare0.52%—+58.22%
42GPCRStructure Therapeutics INCStock-Other0.51%—+25.68%
43✓ Immatics NVStock-Other0.51%—-13.51%
44CLDXCelldex Therapeutics INCStock-Other0.49%——
45LXEOLexeo Therapeutics INCStock-Other0.49%-0.30%+10.62%
46ALECAlector INCStock-Other0.44%+0.11%—
47VKTXViking Therapeutics INCStock-Healthcare0.44%——
48KURAKura Oncology INCStock-Other0.44%——
49PROFProfound Medical CORPStock-Other0.39%-0.13%-7.95%
50FULCFulcrum Therapeutics INCStock-Other0.36%+0.36%NEW
1–50 of 83

Holding changes this quarter

DAFNA Capital Management LLC's most significant position changes for 2026-03-31: Sold out: Astria Therapeutics INC (CATBUSD); New buy: Fulcrum Therapeutics INC (FULC); New buy: Orthopediatrics CORP (KIDS); New buy: Cytomx Therapeutics INC (CTMX); New buy: Maze Therapeutics INC (MAZE).

Position changes disclosed by DAFNA Capital Management LLC for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#TickerIssuerWeight ChangeShares ChangeAction
1DAWNGBXDay One Biopharmaceuticals I+2.6%-2.07%Trim
2NKTRNektar Therapeutics+2%+120.24%Add
3CMPSCompass Pathways PLC+1.7%+198.24%Add
4RVMDRevolution Medicines INC+1.7%-3.94%Trim
5LRMRLarimar Therapeutics INC+1.3%+116.06%Add
6BCAXBicara Therapeutics INC+0.9%+61.22%Add
7IPSCCentury Therapeutics INC+0.6%-12.86%Trim
8XENEXenon Pharmaceuticals INC+0.3%-12.91%Trim
9ALLOAllogene Therapeutics INC+0.3%-0.72%Trim
10ALKSAlkermes plc+0.3%+7.09%Add
11MPLTMaplight Therapeutics INC+0.2%+18.95%Add
12RAREUltragenyx Pharmaceutical In+0.2%+281.88%Add
13DNLIDenali Therapeutics INC+0.2%—Unchanged
14BCRXBiocryst Pharmaceuticals INC+0.2%+2.87%Add
15STOKStoke Therapeutics INC+0.2%+20.21%Add
16NGNENeurogene INC+0.1%+102.46%Add
17ALECAlector INC+0.1%—Unchanged
18PROFProfound Medical CORP-0.1%-7.95%Trim
19✓ Mediwound LTD-0.1%-16.91%Trim
20VRCAVerrica Pharmaceuticals INC-0.2%-11.38%Trim
21✓ Proqr Thrapeutics N V-0.2%—Unchanged
22ANNXAnnexon INC-0.2%-56.82%Trim
23ASNDAscendis Pharma A/S-0.2%-17.75%Trim
24TELATela Bio INC-0.2%—Unchanged
25PRCTProcept Biorobotics CORP-0.2%—Unchanged
26SNDXSyndax Pharmaceuticals INC-0.2%-21.77%Trim
27AQSTAquestive Therapeutics INC-0.2%-2.00%Trim
28NBIXNeurocrine Biosciences INC-0.2%—Unchanged
29RCUSArcus Biosciences INC-0.2%+2.90%Add
30SPRYArs Pharmaceuticals INC-0.3%-26.72%Trim
31TNDMTandem Diabetes Care INC-0.3%—Unchanged
32IBBIshares Biotechnology ETF-0.3%-8.81%Trim
33LXEOLexeo Therapeutics INC-0.3%+10.62%Add
34HELPCybin INC-0.3%+9.53%Add
35IDYAIdeaya Biosciences INC-0.5%-5.92%Trim
36BHVNBiohaven Ltd.-0.9%-11.46%Trim
37STXSStereotaxis INC-1.6%—Unchanged
38ATRCAtricure INC-1.6%—Unchanged
39AXGNAxogen INC-1.7%-47.58%Trim
40CYTKCytokinetics INC-2.2%-41.38%Trim
41CATBUSDAstria Therapeutics INC—EXITSold out
42FULCFulcrum Therapeutics INC—NEWNew buy
43KIDSOrthopediatrics CORP—NEWNew buy
44CTMXCytomx Therapeutics INC—NEWNew buy
45MAZEMaze Therapeutics INC—NEWNew buy
46SCYXEURScynexis INC—NEWNew buy
47ERASErasca INC—EXITSold out
48ZBIOZenas Biopharma INC—NEWNew buy
49NAMSNewAmsterdam Pharma Company N.V.—NEWNew buy
50PLRXPliant Therapeutics INC—NEWNew buy

FAQ

What is DAFNA Capital Management LLC and what type of investor is it?
DAFNA Capital Management LLC is a investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-03-31), the firm manages a tracked equity portfolio valued at approximately $439.6M, spread across 83 disclosed positions.
What are DAFNA Capital Management LLC's largest equity positions?
Based on the latest 13F filing, DAFNA Capital Management LLC's top holdings by market value are: 1. Revolution Medicines INC (RVMD) — $56.5M (12.8%) 2. Ss Spdr S&p Biotech ETF (XBI) — $40.7M (9.3%) 3. Stereotaxis INC (STXS) — $25.2M (5.7%) 4. Day One Biopharmaceuticals I (DAWNGBX) — $21.0M (4.8%) 5. Atricure INC (ATRC) — $17.0M (3.9%)
What changes did DAFNA Capital Management LLC make in its most recent portfolio filing?
In the latest reported quarter, DAFNA Capital Management LLC made 41 notable position adjustments: 8 new positions were initiated, 13 existing holdings were added to, 18 positions were partially reduced, and 2 were completely exited. The largest of these moves: Sold out: Astria Therapeutics INC (CATBUSD); New buy: Fulcrum Therapeutics INC (FULC); New buy: Orthopediatrics CORP (KIDS); New buy: Cytomx Therapeutics INC (CTMX); New buy: Maze Therapeutics INC (MAZE)
What sectors does DAFNA Capital Management LLC focus on?
DAFNA Capital Management LLC is concentrated in the following sectors based on its current disclosed equity portfolio: • Health Care: 100.0%